WebNov 10, 1997 · The first is shifting the keto-enol tautomerization of guanine towards the enol form (rare in DNA) in the presence of cisplatin. The second is the action of cisplatin on the guaninecytosine pairing in DNA through binding to the O6 site of guanine which is involved in one of three hydrogen bonds between these nucleic bases. WebCisplatin is a substance used to treat some forms of cancer. Inside cells, each cisplatin molecule forms two chemical bonds with a DNA molecule. The diagram shows part of a DNA molecule with cisplatin attached. Name A and B. The nitrogenous bases. Both bonds form with the same base.
Cisplatin - Wikipedia
WebJan 30, 2013 · In addition to the conventional binding sites of native adenine, complexes with N7-H tautomers have also been considered. In agreement with computational results, the IR characterization of cis- [Pt (NH (3)) (2) (G)Cl] (+) points to a covalent structure where Pt is bound to the N7 atom of guanine. WebNov 19, 2003 · The thermodynamics and kinetics for the monofunctional binding of the antitumor drug cisplatin, cis-diamminedichloroplatinum(II), to a purine base site of DNA … birch bay wa tide schedule
Effect of cisplatin binding on guanine in nucleic acid: an ab initio ...
WebJun 2, 2008 · NMR and X-ray structural characterization of a cisplatin analogue able to slow down the Pt-N7 rotation of a coordinated guanine base by a billion-fold times: 2,2'-bipiperidine (dimethylmalonato)platinum (II) complex Authors Francesco P Intini 1 , Renzo Cini , Gabriella Tamasi , Michael B Hursthouse , Giovanni Natile Affiliation WebDec 1, 2003 · The influence of methionine-containing peptides on the reaction of carboplatin with 5'-guanosine monophosphate: a comparison with cisplatin J Inorg Biochem . 2003 … WebDec 23, 2004 · Finally, the effect of platination on the pairing of guanine with cytosine is studied in a similar manner, revealing large redistributions of hydrogen bonding but surprisingly small overall changes in pairing energy. * Author for correspondence. E-mail: [email protected]. Phone: 029 20874950. Fax: 029 20874030. Supporting Information … dallas cowboys cheerleader adult costume