Cisplatin hearing loss thesis

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August undefined, 2024

WebSep 24, 2024 · As cisplatin is an effective treatment for cancer, researchers have focused on finding ways to counteract the associated hearing loss. Combination therapies, where a protective compound (otoprotectant) such as antioxidants, anti-inflammatories, and steroids are administered alongside cisplatin, aim at decreasing the probability of the patient ... WebAug 25, 2024 · Platinum containing chemotherapeutic agents are associated with cochleotoxicity, characterized by high frequency hearing loss. Cisplatin and related …

Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its …

WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by … WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … shared channels restrictions

Atorvastatin is associated with reduced cisplatin-induced hearing …

WebSep 4, 2024 · Scientists have found out why Cisplatin causes hearing loss. Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. Cisplatin and similar platinum-based drugs are prescribed for an estimated 10 to 20 percent of all cancer patients. WebJun 1, 2024 · Hearing loss likely occurs in all cancers that are treated with cisplatin. Cisplatin is the most ototoxic drug in clinical use. It also happens to be a fantastic … WebDec 18, 2024 · December 18, 2024. Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear. shared channels in ms teams

NIH study uncovers clues about why common cancer drug causes hearing loss

Cisplatin and hearing loss - See why it causes hearing loss - Hear-it.org

WebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the etiology … WebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin … shared channels + microsoft teamsWebMar 24, 2014 · Detailed Description: The study is a dose-finding study of N-acetylcysteine (NAC) to protect hearing in children receiving cisplatin for the treatment of their cancer. NAC also has potential to protect the kidneys from cisplatin toxicity. The study uses a 3+3 dose-escalation scheme to determine the dose of NAC necessary to achieve serum … shared channels microsoft

"WebBackground: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss. Methods: A retrospective review of 993 pediatric patients’ medical and audiological " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

CISPLATIN-INDUCED OTOTOXICITY. PHARMACOKINETICS, …

WebImproved survival from childhood cancer has been achieved at the cost of long-term comorbidities that reduce quality of life. The chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced hearing loss, a debilitating and permanent late … WebOct 27, 2024 · In the pediatric population, cisplatin-induced hearing loss within the speech range can have a profound impact on cognitive development, leading to life-long complications 6,7,8.

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WebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. … WebThe impact of hearing loss can be devastating and is often associated with tinnitus, imbalance, or a debilitating sensitivity to sound. Cisplatin is commonly used with curative intent. As such, protecting the patient’s quality of life after cisplatin chemotherapy should be of high interest to both physicians and patients.

WebSynthese und Charakterisierung von neuen Dicobalthexacarbonyl-Komplexen als Cycl... 9 Referenzen [1] Titelblatt WebJul 13, 2024 · “Around 60% to 80% of kids who get cisplatin have significant hearing loss,” Dr. Neuwelt explained. The impact of that hearing loss can be profound, he continued, including greatly increasing the risk …

WebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk … WebJan 1, 2024 · Cisplatin-induced hearing loss is permanent, and there are currently no FDA-approved therapies to reduce or prevent cisplatin ototoxicity. Here we explore the …

WebJun 3, 2024 · The topic of my MSc thesis work was “Synthesis and Characterization of CuO-PVA Nanofluid for Heat Transfer Applications”. ... Cisplatin-induced ototoxicity (CIO), manifests as permanent, bilateral, high frequency sensorineural hearing loss that is estimated to affect 26-90% of children that has debilitating effects on children’s ...

WebNov 29, 2024 · Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 ... shared channels ms teamsWebCisplatin may cause serious hearing problems, especially in children. Hearing loss may be permanent in some cases. Your doctor will order tests to monitor your hearing before and during your treatment. Tell your doctor and pharmacist if you have ever had radiation therapy to your head. Tell your doctor and pharmacist if you are taking ... shared channel teams gcc poolsafe glass fencing byron bayWebMar 26, 2024 · The severity of cisplatin-related ototoxicity is associated with age and the cumulative dose received: the younger the child and the higher the total dose, the more severe the hearing loss may be. The spectrum of hearing loss varies from mild to moderate high tone hearing loss, to profound loss across the hearing range and … shared channel teamsWebHigh-dose cisplatin treatment: hearing loss and plasma concentrations. Fifty-four patients with metastatic cancer were followed audiometrically during high-dose (100-120 mg/m2) … shared channels teams connectWebCISPLATIN-INDUCED HEARING LOSS IN CHOP KO MICE 2 Abstract Cisplatin is a chemotherapeutic drug that causes hearing loss, and the mechanisms of its ototoxicity … poolsafe fencingWebAug 31, 2016 · Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin’s ototoxic … poolsafely.gov