WebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, tachycardia, and hypotension. Hypersensitivity reactions have occurred within minutes of administration to patients with prior exposure toCisplatin for injection. WebNov 5, 2024 · Cisplatin-based chemotherapy (CBCT) is essential in the treatment of metastatic testicular cancer (TC) but has been associated with long-term risk of …
Targeted therapy for cisplatin‐resistant lung cancer via …
WebAfter right heart catheterization, pathological results of a myocardial biopsy from the ventricular septum indicated no cardiac muscle hypertrophy, cardiac fibrosis, … WebCytostatic antibiotics of the anthracycline class are the best known of the chemotherapeutic agents that cause cardiotoxicity. Alkylating agents such as cyclophosphamide, … greenstar i system compact
Cisplatin in cancer therapy: molecular mechanisms of action
WebFeb 23, 2024 · The first step in the algorithm is to determine if a patient is fit to receive cisplatin based on 4 key aspects of the Galsky criteria, which include performance status, peripheral neuropathy,... Cisplatin has a number of side effects that can limit its use: • Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major clinical concern. Cisplatin selectively accumulates into the proximal tubule via basolateral-to-apical transport, where it disrupts mitochondrial energetics and endoplasmic reticulum Ca homeostasis and stimulates reactive oxygen species and pro-inflammatory cytokines. Multiple mitigation strate… WebMar 11, 2024 · Heart failure occurs when the heart muscle doesn't pump blood as well as it should. When this happens, blood often backs up and fluid can build up in the lungs, causing shortness of breath. Certain heart … greenstar i thermostat