Cisplatin target

Author: qbzm

August undefined, 2024

WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, such … WebJul 28, 2024 · Many of the most commonly prescribed chemotherapeutics, including platinum-based compounds such as cisplatin, target the characteristic genomic instability of tumors by directly damaging the …

A Combined Systemic Strategy for Overcoming Cisplatin

WebMar 1, 2024 · GRP78 and its downstream target AKT are important in regulating cisplatin resistance in ER stress-tolerant human lung cancer cells [197]. Inhibition of GRP78 by siRNA sensitizes drug-resistant human melanoma cells to cisplatin- and doxorubicin-induced apoptosis [198] . WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … butler\u0027s muffler \u0026 auto repair leavenworth

Gene scissors find target for testicular cancer therapy

WebJan 10, 2024 · Characterization of cisplatin-loaded chitosan nanoparticles and rituximab-linked surfaces as target-specific injectable nano-formulations for combating cancer Characterization of cisplatin-loaded chitosan nanoparticles and rituximab-linked surfaces as target-specific injectable nano-formulations for combating cancer Authors National Center for Biotechnology Information www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov WebJan 13, 2011 · Cisplatin is one of the most effective chemotherapeutic agents against many forms of cancer including testicular, bladder, head and neck, ovarian, breast, lung, … cdfw annual leave

Cisplatin - Drug Information - Chemocare

WebApr 13, 2024 · Testicular cancer, also known as testicular germ cell tumors (TGCT), is the most common type of cancer in young men. When treated with cisplatin, the tumor cells stop growing and die. This is because the cytostatic drug causes damage to DNA, the carrier of genetic information, thus stopping the cell cycle. "The alarm signal is sent … Web1 day ago · Pomiferin potentiates the tumor suppression effect of cisplatin via attenuating ABCB1 activity and promoting cisplatin accumulation in tumor tissues of RM-1 drug-resistant prostate cancer bearing C57BL/6 mouse model. (A) ... Antigen retrieval was completed by using Dako Target Retrieval Solution in low pH (pH 6.1) at 97 °C for 20 ... butler\u0027s new albany msWebOct 2, 2024 · Cisplatin is a platinum compound which is widely used in the treatment of various solid tumors including ovarian cancer. Up to now, the mechanism of cisplatin resistance in ovarian cancer is unclear. butler\u0027s muffler \u0026 auto repair leavenworth ks

"WebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions … " - Cisplatin target

Cisplatin target

Review of the Comparative Pharmacology and Clinical Activity of ...

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared.

Did you know?

WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... Aptamer-targeted nano-zinc carriers were loaded with USP14 siRNA to target DDP ... WebJun 13, 2005 · Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Brand Names. Platinol. …

WebGene scissors find target for testicular cancer therapy April 11 2024 Culture of testicular cancer cells under Cisplatin at day 28: While the cells on the left almost all dead, individual cells in ... WebJan 6, 2024 · Cisplatin-related genes were downloaded from GeneWeaver. The protein-protein interaction (PPI) network was created using the STRING database. A drug-bioactive compound-disease-target network was constructed using Cytoscape. GO and KEGG analyses were performed to investigate common targets of quercetin and cisplatin in …

The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University discovered that electrolysis of platinum electrodes generated a soluble platinum complex which inhibited binary fission in Escherichia coli (E. coli) bacteria. Although bacterial cell growth continued, cell division … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …

WebWe are a leading protocol organizations within the National Clinical Trials Network and we seek to improve the lives of cancer patients by conducting practice-changing, multi-institutional clinical and translational research. Learn More Donate Today $25 $50 $75 $100 Other NRG Oncology Foundation, Inc, is a nonprofit, tax-exempt foundation.

WebWe found that miR-195-5p might play a role as an oncogene in LC cells and have an inhibitory effect on chemotherapy resistance to cisplatin. Afterward, by target gene prediction and confirmation, it was concluded that miR-195-5p might directly target downstream gene FGF2 to affect the resistance to cisplatin and migration invasion … cdfw badgerWebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. cdfw bishop officeWebCisplatin is administered through a vein (intravenously or IV) as an infusion. There is no pill form of cisplatin. Cisplatin is an irritant. An irritant is a chemical that can cause … cdfw avian fluWebNov 23, 2024 · Cisplatin is the first-line chemotherapy agent for head and neck cancer (HNC), but its therapeutic effects are hampered by its resistance. In this study, we … butler\u0027s near meWebOct 23, 2003 · Interestingly, cisplatin also activates CHK2, which is a downstream target of ATM, but the effect of cisplatin on CHK2 appears to be independent of ATM (Damia et al., 2001). cdfw cemafWebJul 1, 2024 · The main target of cisplatin is genomic DNA (gDNA) but a very little amount (∼1%) of intercellular cisplatin is generally bound to gDNA [58]. Several proteins like … butler\u0027s nurseryWebOct 31, 2024 · Here, we demonstrate that targeting PAPSS1 in conjunction with cisplatin treatment leads to better response rates in vivo. Clinically, we discovered that low PAPSS1 expression is associated with increased survival rates in chemotherapy-treated NSCLC and ovarian cancer patients. cdfw bishop field office